Daniel Wagenaar Thesis

By growing cultures on multi-electrode arrays (Petri dishes with a grid of substrate-embedded electrodes), their electrical activity can be recorded non-invasively.

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Past funding came from the Burroughs Wellcome Fund in the form of a Career Award at the Scientific Interface, from the University of Cincinnati and from The Broad Foundations.

All support, past and present, is gratefully acknowledged.

Armed with his many suggestions, I would then rewrite the thing, until he gave it his sign of approval, “it reads like a novel.” Jerry always demanded absolute scientific integrity.

If you tried to make a claim based on dubious data, he’d say, “that is nonsense, and you know it.

Let me begin by thanking Jerry Pine and Steve Potter, the best advisers I could have wished for.

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From the moment I first stepped into Jerry’s lab, when I visited Caltech as a prospective, I knew it would be a good place to work.

Indeed, by feeding cultures a steady stream of stimuli, distributed over many electrodes, bursting could be prevented completely.

The number of electrodes required for successful burst control could be reduced by fine-tuning the stimuli with real-time feedback, to make each stimulus evoke the same number of spikes.

In contrast to earlier published reports, I found that none of them induced changes in burst patterns or responses to test pulses that exceeded spontaneously occurring changes.

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